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doi: 10.1038/s41467-022-33323-8 104 JakimiukAJWeitsmanSRNavabAMagoffinDA

In 1968, in a double-blind, placebo-controlled trial, 108 overweight or obese women were categorized into three groups that received continuously or intermittently (every 4 weeks) dosed phentermine or placebo, respectively

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Route/evidence mismatch: the pivotal mouse study tested subcutaneous injection at a fixed research dose (20 mg/kg, three times daily) the oral capsule use that is actually sold and discussed commercially has not itself been directly tested in that published research